![]() ![]() One hypothesis is that by reversing the sequence, the resulting folds would be mirror-images of the original fold. By comparing palindromes with set sequences from the database, scientists can try to find the roles of palindromic sequences.Īnother topic within palindromic sequences which is being studied is whether the symmetry of palindromic sequences affects the structure and folds of peptides. ![]() Some of these protein groups include DNA binding proteins, ion channels and Rhodopsin, metal binding proteins and receptors, and etc. Scientists suggest that these sequences are important for protein structure and protein function in different proteins. Studies have shown that the frequent appearances of palindromic sequences, also called palindromic peptides, in protein sequences are not just by chance. There have been many researchers who have studied the relationship between palindromic sequences and protein structures. A = Palindrome, B = Loop, C = Stem Relationship between Sequence and Protein Structure ![]() When the complementary strand is read backwards, the sequence is 5’-GGATCC-3’ which is identical to the first one, making it a palindromic sequence.Īnother restriction enzyme called EcoR1 recognizes and cleaves the following palindromic sequence:ĥ’ – G A A T T C – 3’ 3’ – C T T A A G – 5’ Palindrome Image of a palindrome in a DNA structure. This is the sequence where the restriction endonuclease, BamHI, binds to and cleaves at a specific cleavage site. An example of a palindromic sequence is 5’-GGATCC-3’, which has a complementary strand, 3’-CCTAGG-5’. So if a sequence is palindromic, the nucleotide sequence of one strand would be the same as its reverse complementary strand. The pairing of nucleotides within the DNA double-helix is complementary which consist of Adenine (A) pairing with either Thymine (T) in DNA or Uracil (U) in RNA, while Cytosine (C) pairs with Guanine (G). It is also known as a palindrome or an inverted-reverse sequence. Palindromic Sequencing Ī palindromic sequence is a sequence made up of nucleic acids within double helix of DNA and/or RNA that is the same when read from 5’ to 3’ on one strand and 5’ to 3' on the other, complementary, strand.
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